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About 31% of the patients with a factor VIII replacement therapy develop a factor VIII inhibitor.From these are 23% low-responder ( 5BE) [8].In the case of severe hemophilia B, about 10.5% of the patients develop inhibitory antibodies [9]. Anti-factor VIII-antibodies are also seen in 15-78% healthy people without hemophilia [7, 17, 19]. Lacroix-Desmazes et al. [10, 11] showed anti-idiotypic antibodies neutralizing the inhibitory activity of the an- factor VIII antibodies in healthy people. Well-known predisposing factors for inhibitor formation are genetic features of factor VIII, which include large deletions, nonsense mutations or intrachromosomal recombinations [5, 23].Also, ethnic groups other than Caucasians (e.g.Africans) have a higher risk of developing inhibitors.Other risk factors are presumably de- ved from the immune system. For instance, a reduction of the inhibitor was seen with lower CD4+ T helper cell counts in HIV positive hemophilic patients [3,4].The development of inhibitors is very likely to be a Th-2 mediated event where cyto- nes and their receptors, T-cell receptors and the Major Histocompatibility Complex may also play an important role. Theoretical Background The substituted factor is an unknown protein for patients with a severe he- philia. Fig. 1. The normal immunoresponse (according to BAENKLER [2]) Abbreviations: TCR - T cell-receptor; APC - antigen presenting cell 36 I.Wieland et al. [PDF] 36th Hemophilia Symposium Hamburg 2005: Epidemiology ... ... 36th Hemophilia Symposium Hamburg 2005: Epidemiology Hemophilia ... 33rd Hemophilia Symposium Hamburg ... 36th Hemophilia Symposium Hamburg 2005: ... 36th Hemophilia Symposium Hamburg 2005 - Bokus.com 36th Hemophilia Symposium Hamburg 2005 ... Source of Information about the Quality of Hemophilia Medical Care in a Developing Country.- Hemophilia Therapy ... 36th Hemophilia Symposium Hamburg 2005 (eBook 2007 ... Get this from a library! 36th Hemophilia Symposium Hamburg 2005. ... The main topics are epidemiolgy hemophilia therapy orthopedic treatment in hemophiliacs ... 36th Hemophilia Symposium Hamburg 2005 Epidemiology ... Title Book : 36th Hemophilia Symposium Hamburg 2005 Epidemiology Hemophilia Therapy Management Of Bleedings An; Category : Uncategorized; Author : Undefined; 36th Hemophilia Symposium Hamburg 2005 - Issuu 36th Hemophilia Symposium Hamburg 2005. DOWNLOAD HERE. This book contains the contribution to the 36th Hemophilia Symposium Hamburg 2005. The main topics are ... 36th Hemophilia Symposium Hamburg 2005 - Epidemiology ... 36th Hemophilia Symposium Hamburg It seems that you're in USA. We have a dedicated site ... 36th Hemophilia Symposium Hamburg 2005 Epidemiology; Hemophilia Therapy ... 36th Hemophilia Symposium Hamburg 2005: Epidemiology ... 36th Hemophilia Symposium Hamburg 2005 and over one million other books are available for Amazon Kindle. Learn more 36th Hemophilia Symposium : Hamburg 2005 (eBook 2007 ... Hemophilia Symposium (36th : 2005 : Hamburg Germany). 36th ... worldcat.org/oclc/184984746 36th Hemophilia Symposium : Hamburg 2005 a ... 36th Hemophilia Symposium Hamburg 2005 - Springer 36 th Hemophilia Symposium Hamburg 2005. ... HIV Infection and Causes of Death in Patients with Hemophilia in Germany (Year 2004/2005 Survey) H. Krebs W. Schramm. 36th Hemophilia Symposium Hamburg 2005 - Epidemiology ... 36th Hemophilia Symposium Hamburg This website uses cookies. By using our website and ... 36th Hemophilia Symposium Hamburg 2005 Epidemiology; Hemophilia Therapy ...
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